TAKOTSUBO SYNDROME AS ACUTE FORM OF MICROVASCULAR ANGINA. CLINICAL CASE
https://doi.org/10.20996/1819-6446-2017-13-4-489-494
Abstract
The mechanisms of stress-induced cardiomyopathy (takotsubo syndrome) have not been fully determined. A clinical case of the development of stressinduced cardio-myopathy in a patient with microvascular angina is presented. A 73-year-old woman was hospitalized to the cardiology clinic with a diagnosis of acute circular myocardial infarction (elevation ST II, III, aVF, V2-6, positive troponin test). According to coronary angiography stenosis of coronary arteries were not identified. According to echocardiography the following abnormalities were revealed: decrease in global contractility of the myocardium, hyperkinesia of the basal parts of the left ventricle and at the same time akinesia of the apex and hypokinesia of the middle segments of the left ventricle. After 1 month a contractility of the myocardium was normal, there were no zones of violation of contractility. It was suggested that the patient had takotsubo syndrome. Anginal pain due to physical and emotional stress with unchanged coronary arteries suggested primary microvascular angina. It was confirmed by the presence of endothelium-dependent vasodilation disorders that were revealed by positron emission tomography of myocardium with cold pressor test and peripheral arterial tonometry. This clinical case demonstrates one of the discussed pathogenetic mechanisms of the takotsubo syndrome – generalized microvascular spasm. As the patient suffered previously from chronic microvascular angina, it seems logical in this case to regard stress-induced cardiomyopathy as an acute form of microvascular angina.
About the Authors
S. A. Boldueva
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
MD, PhD, Professor, Head of Chair of Faculty Therapy,
Kirochnaya ul. 41, St-Petersburg, 191015
M. V. Ryzhikova
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
MD, Cardiologist, Department of Cardiology for Treatment of Patients with myocardial infraction, Clinic named after Peter the Great,
Kirochnaya ul. 41, St-Petersburg, 191015
N. S. Shvets
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
MD, Head of Department of Cardiology for Treatment of Patients with myocardial infraction, Clinic named after Peter the Great,
Kirochnaya ul. 41, St-Petersburg, 191015
I. A. Leonova
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
MD, PhD, Associate Professor, Chair of Faculty Therapy,
Kirochnaya ul. 41, St-Petersburg, 191015
I. Yu. Titova
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
MD, Department of Functional Diagnostics, Clinic named after Peter the Great,
Kirochnaya ul. 41, St-Petersburg, 191015
I. N. Kochanov
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
MD, Head of Interventional Radiology Department, Clinic named after Peter the Great,
Kirochnaya ul. 41, St-Petersburg, 191015
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Review
For citations:
Boldueva S.A., Ryzhikova M.V., Shvets N.S., Leonova I.A., Titova I.Yu., Kochanov I.N. TAKOTSUBO SYNDROME AS ACUTE FORM OF MICROVASCULAR ANGINA. CLINICAL CASE. Rational Pharmacotherapy in Cardiology. 2017;13(4):489-494. (In Russ.) https://doi.org/10.20996/1819-6446-2017-13-4-489-494
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