Differences in the Incidence of Major Risk Factors in Patients with Ischemic or Hemorrhagic Stroke in the Siberian Population

Background. The study of the incidence of risk factors (RF) of stroke for primary and secondary prevention of this disease remains relevant. There are modifiable and non-modifiable RF.

Aim. To study the frequency of the main RF in patients with ischemic and hemorrhagic stroke in the urban population of Krasnoyarsk (Eastern Siberia).

Material and methods. Examination of 124 patients with an ischemic stroke and 28 with hemorrhagic was performed. Patients received treatment in neurologic center of Krasnoyarsk in 2014 year. The main criterion of inclusion was the confirmed diagnosis of an ischemic or hemorrhagic stroke. All patient had the clinic-tool and neurovisualizing examination and collecting the individual and family anamnesis with examination of modifiable and non-modifiable RF. The research of the neurologic status at patients both with ischemic, and with a hemorrhagic stroke was conducted by the standard technique. Based on results of computer or magnetic resonance imaging of a brain the diagnosis of an ischemic or hemorrhagic stroke was established.

Results. A distinctive feature of patients with hemorrhagic stroke was the occurrence of a vascular accident in younger age (6 years earlier) in comparison with ischemic stroke. Among patients with ischemic stroke elevated body mass index (BMI) was in 87 (70.2%) patients, burdened heredity was in 8.1% of cases, and 43.5% of patients were smokers. Among patients with hemorrhagic stroke 16 (57.1%) patients had elevated BMI. People with burdened heredity were not identified among them. Smoking was found in 22 (78.6%) patients in this group.

Conclusion. Improvement of treatment and prevention of an ischemic stroke are in many respects connected with clarification of RF and pathogenic mechanisms of its development. The rational pharmacotherapy directed to pointed impact on individual RF can reduce the risk of development of stroke not only at individual, but also at the population level.

1. Skvortsova V.I., Koltsova E.A., Kimelfeld E.I. Comparative analysis of risk factors and pathogenic types of ischemic stroke in young and old patients. Kursk Scientific and Practical Bulletin "Man and His Health" 2012;3:81-7. (In Russ.).

2. Lebedev I.A. Prevalence and risk factor structure of cerebral stroke in people of the Khanty-Mansi Autonomous Region. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;12(2):70-6. (In Russ.).

3. Doronin B.M., Mongush Kh.D., Ondar A.B., Chylbakool R.Ch. Comparative analysis of risk factors for stroke among native peoples Republic of Tyva. Byulleten' Sibirskoy Meditsiny. 2013;12(5):31-8. (In Russ.).

4. Magomaev M.F. Analysis of risk factors for stroke in the plains and the mountains of Dagestan. Vrachaspirant. 2012;51(2.4):589-96. (In Russ.)

5. Pyshkina L.I., Kabanov A.A., Alibekova Zh.M. Demographic characteristics of risk factors of ischemic stroke in the Dagestan Republic. . C.C. Korsakov Journal of Neurology and Psychiatry. 2014;8(2):65-8. (In Russ.).

6. Hasanova N.M. The urgency of the issue and some aspects of stroke risk factors in the context of the European North. Byulleten' Severnogo Gosudarstvennogo Meditsinskogo Universiteta. 2004;1:263-5. (In Russ.).

7. Platonov A.E., Tanashyan M.M., Illarioshkin S.N., et al. Composite evaluation of genetic risk factors for ischemic stroke and algorithm calculating the individual risk of the disease. Materials of 9th AllRussia Scientific Conference with International Participation “Molecular Diagnostics 2017”. April 1820, Moscow, Russia. Moscow: Meditsina; 2017:90-4. (In Russ.).

8. Anisimova A.V., Gunchenko A.S., Avdonina M.A., et al. Clinical features and genetic risk factors in the development of ischemic stroke. Ural'skiy Meditsinskiy Zhurnal. 2017;9:22-9. (In Russ.).

9. Nikulin D.A., Nikulina S. YU., Chernova A.A., et al. The role of ROS1 gene in development of stroke. Russian Journal of Cardiology. 2015;10:46-9. (In Russ.).

10. Nikulin D.A., Shulman V.A., Prokopenko S.V., et al. Interrelation of polymorphic allelic rs619203 option of a gene receptor of a tirozinkinaza (ROS1) with cardiovascular diseases at patients with an ischemic stroke. CardioSomatika. 2015;2:6-11. (In Russ.).

11. Fleiss JL, Levin B, Paik MC. Statistical methods for rates and proportions. 3rd ed. New Jersey: John Wiley & Sons; 2003.

12. Kaerova E.V., Zhuravskaya N.S., Matveeva L.V., Shestera A.A. Major risk factors of the heart stroke development. Sovremennye Problemy Nauki i Obrazovanija. 2017;6:133. (In Russ.).

13. Kobylina O.V., Nikolaeva T.Ja. Comparative analysis of risk factors for ischemic stroke in the Yakut ethnic group. Jakutskij Medicinskij Zhurnal. 2008;1:8-11. (In Russ.).

14. Mashin V.V., Grishchuk D.V., Albert M.A. The risk factors and markers of various subtypes of ischemic stroke. Ul'yanovskiy Mediko-Biologicheskiy Zhurnal. 2013;1:8-14. (In Russ.).

15. Erkebaeva S.K., Nurguzhaev E.S., Gafurov B.G., et al. Epidemiology and climate and geographic risk factors of stroke in the South Kazakhstan oblast. S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(3-2):3-8. (In Russ.).

16. Hasanova N.M., Popov V.V. Prevalence and risk factors for stroke in Arkhangelsk : monograph. Arkhangelsk: Izdatel'stvo Severnogo gosudarstvennogo meditsinskogo universitet; 2012. 108 p. (In Russ.).

17. Bogatyreva M.D., Stakhovskaya L.V. Risk factors for ischemic stroke among the rural population of the Stavropol territory. Nevrologiya, Neyropsikhiatriya, Psikhosomatika. 2012;4:58-61. (In Russ.).

18. Khutieva L.S., Efremov V.V. Structure, outcomes and risk factors of strokein the Republic of Ingushetia (according to the register of stroke). Fundamental'nye Issledovanija. 2013;3-2:400-3. (In Russ.).

19. Parfenov V.A., Verbickaja S.V. Risk factors and pathogenetic subtypes of ischemic stroke. Aterotromboz. 2012;1:16-25. (In Russ.).

20. Meshkova K.S., Gudkova V.V., Stahovskaja L.V. Risk factors and prevention of stroke. Zemskij Vrach. 2013;2:16-9. (In Russ.).

21. Lutsky M.A., Frolov V.M., Bykovа V.A. Ischemic stroke risk factors. Sistemnyy Analiz i Upravleniye v Biomeditsinskikh Sistemakh. 2012;11(2):353-5. (In Russ.).