KОРРЕКЦИЯ ЛИПИДНОГО ОБМЕНА С ИСПОЛЬЗОВАНИЕМ АНТИСЕНС-ТЕХНОЛОГИЙ
https://doi.org/10.20996/1819-6446-2013-9-5-532-541
Аннотация
Обсуждают использование антисмысловых олигонуклеотидов (АСО) для разработки препаратов для коррекции нарушений липидного обмена. Анализируют основные типы АСО и механизмы их действия на целевую мРНК. Рассматривают достоинства и недостатки различных АСО с точки зрения требований для их терапевтического применения.
Описывают методы химической модификации олигонуклеотидов; преимущества и недостатки различных способов доставки АСО препаратов в клетки; состояние разработок крупнейшими фармакологическими компаниями АСО препаратов для коррекции нарушений липидного обмена; данные, полученные при проведении клинических испытаний таких препаратов.
Об авторах
О. И. Афанасьева
Российский кардиологический научно-производственный комплекс, Москва
Россия
Доктор биологических наук, ведущий научный сотрудник лаборатории проблем атеросклероза института экспериментальной кардиологии
Россия
Доктор биологических наук, ведущий научный сотрудник лаборатории проблем атеросклероза института экспериментальной кардиологии
С. Н. Покровский
Российский кардиологический научно-производственный комплекс, Москва
Россия
Доктор биологических наук, профессор, руководитель лаборатории проблем атеросклероза института экспериментальной кардиологии
Россия
Доктор биологических наук, профессор, руководитель лаборатории проблем атеросклероза института экспериментальной кардиологии
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Рецензия
Для цитирования:
Афанасьева О.И., Покровский С.Н. KОРРЕКЦИЯ ЛИПИДНОГО ОБМЕНА С ИСПОЛЬЗОВАНИЕМ АНТИСЕНС-ТЕХНОЛОГИЙ. Рациональная Фармакотерапия в Кардиологии. 2013;9(5):532-541. https://doi.org/10.20996/1819-6446-2013-9-5-532-541
For citation:
Afanasieva O.I., Pokrovsky S.N. LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY. Rational Pharmacotherapy in Cardiology. 2013;9(5):532-541. (In Russ.) https://doi.org/10.20996/1819-6446-2013-9-5-532-541
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