Role of Speckle Tracking in the Evaluation of Left Ventricular Remodeling After Streptokinase Infusion in Patients with Acute Anterior Myocardial Infarction
https://doi.org/10.20996/1819-6446-2020-11-04
Abstract
Background. Left ventricular (LV) remodeling is an adverse consequence after acute myocardial infarction.
Aim. To assess the role of speckle tracking in the evaluation of LV remodeling after streptokinase infusion in patients with acute anterior ST-segment elevation myocardial infarction (STEMI).
Material and methods. A total of 200 patients with first acute anterior STEMI received streptokinase as a reperfusion therapy were included. Conventional echocardiography and speckle tracking were performed within 3 days of admission and 3 months later. According to the development of LV remodeling, patients were classified into two groups. Group (I) patients with LV remodeling (60 patients) and group (II) patients without remodeling (140 patients).
Results. Patients with LV remodeling had lower global longitudinal (GLS) and circumferential (GCS) strain values (-13.19±4.57 vs. -18.90±4.23 % and -13.16±4.27 vs. -17.16±3.3 %, respectively, p<0.001). GLS cutoff value of >-13.5 was shown to have the best diagnostic accuracy (sensitivity =60.0% & specificity =87.1%) in predicting LV remodeling (AUC 0.816, 95% confidence interval [CI] 0.754-0.877, p<0.001). GCS cutoff value of >-16.21 was shown to have the best diagnostic accuracy (sensitivity =75.0% & specificity =71.4%) in predicting LV remodeling (AUC 0.785, 95%CI 0.719-0.85, p<0.001).
Conclusion. Speckle tracking echocardiography either longitudinal or circumferential strain has good sensitivity and specificity in predicting LV remodeling after acute myocardial infarction.
About the Authors
Sh. I. Farag
Benha University
Egypt
Egypt
Shereen Ibrahim Farag - MD, Cardiovascular Medicine Department, Faculty of Medicine, Benha University.
Fareed Nada Street, Benha, Qalubiya Governorate, 13511.
Kh. E. El-Rabbat
Benha University
Egypt
Egypt
Khaled Emad El-Din El-Rabbat - MD, Cardiovascular Medicine Department, Faculty of Medicine, Benha University.
Fareed Nada Street, Benha, Qalubiya Governorate, 13511.
M. A. El-Awadi
Benha University
Egypt
Egypt
Mohamed Ali El-Awadi - MBBCH, Cardiovascular Medicine Department, Faculty of Medicine, Benha University.
Fareed Nada Street, Benha, Qalubiya Governorate, 13511.
A. M. Sabry
Benha University
Egypt
Egypt
AL-Shimaa Mohamed Sabry - MD, Cardiovascular Medicine Department, Faculty of Medicine, Benha University.
Fareed Nada Street, Benha, Qalubiya Governorate, 13511.
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Review
For citations:
Farag Sh.I., El-Rabbat Kh.E., El-Awadi M.A., Sabry A.M. Role of Speckle Tracking in the Evaluation of Left Ventricular Remodeling After Streptokinase Infusion in Patients with Acute Anterior Myocardial Infarction. Rational Pharmacotherapy in Cardiology. 2020;16(6):876-880. https://doi.org/10.20996/1819-6446-2020-11-04
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