Взаимосвязь между химиотерапией и фибрилляцией предсердий: клиническое наблюдение

Цель данной статьи - описание клинического случая фибрилляции предсердий (ФП) на фоне приема множественных неоадъювантных и адъювантных режимов химиотерапии, содержащих препараты как антрациклинового ряда, так и других групп. В данном случае отмеченное нарушение ритма является проявлением кардиотоксичности. Последнее подразумевает степень деструктивного воздействия химиопрепарата на структурно-функциональные параметры сердечно-сосудистой системы. Необходимо отметить, что клиническая манифестация кардиотоксичности может быть как острой, т.е. проявиться непосредственно после введения химиопрепарата (часто при вынужденно высоких кумулятивных дозах), отсроченной, так и иметь поздний характер. Высокоэффективные препараты антрациклинового ряда, кардиотоксичность которых известна достаточно давно, продолжают оставаться практически незаменимыми компонентами многих режимов химиотерапии. Стоит отметить, что сравнительно более новые препараты также обладают кардиотоксическим действием.

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