MICROCIRCULATORY ISCHEMIA AND STATINS: LESSONS OF INTERVENTION CARDIOLOGY
https://doi.org/10.20996/1819-6446-2007-3-1-48-54
Abstract
Review is devoted to the pathogenesis of microcirculatory ischemia. Microcirculatory dysfunction has been identified in different groups of patients including syndrome X, diabetes mellitus 2 type, coronary heart disease. In coronary patients after transluminal angioplasty microcirculatory dysfunction is the reason of phenomenon of “non-reflow”. In result the procedure of revascularization is less effective. Therapy by statins can be beneficial for patients with microcirculatory ischemia.
About the Authors
An. A. Alexandrov
Russian Academy of Medical Sciences, Moscow
Russian Federation
Department of Cardiology, Endocrinology Scientific Center
Russian Federation
Department of Cardiology, Endocrinology Scientific Center
I. I. Tchukaeva
Russian Academy of Medical Sciences, Moscow
Russian Federation
Department of Cardiology, Endocrinology Scientific Center
Russian Federation
Department of Cardiology, Endocrinology Scientific Center
References
1. DeWood MA, Spores J, Notske R et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med, 1980; 303: 897-902.
2. Wtazume H, Iwama T, Kubo I, et al. No-reflow phenomenon during percutaneous transluminal coronary angioplasty. Am Heart J, 1988; 116: 211-215.
3. Aiello EA, Jabr Rl, Cole WC, Arrhythmia and delayed recovery of cardiac action potential during reperfusion after ischemia: role of oxygen radical-induced no-reflow phenomenon. Circ Res., 1995;77: 153-162.
4. Ho H, Maruyama A, Iwakura K, et al. Clinical implications of the "no reflow" phenomenon: a predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation. 1996; 93; 223-228.
5. Marzilli M, Oliozheni E, Marraccini P, et al. Primary coronary angioplasty in acute myocardial infarction: clinical correlates of the "no reflow" phenomenon. Int J Cardiol. I998; 65(suppl I): s23-s28.
6. Monshima 1, Sonc T, Okumura K, et al. Angiographic no-rcflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction. J Am Coll Cardiol., 2000; 36: 1202-1209.
7. DiMario C, Moses JW, Anderson TJ, et al. Randomize comparison of elective stent implantation and coronary baloon angioplasty guided by online quantitative angiograph and intracoronary doppler. Circulation, 2000; 102: 2930-7.
8. Albertal M., Regar E, Van Langenhove G, et al. on behalf of the DEBATE investigators. Flow velocity and predictors of suboptimal coronary flow velocity reserve after coronary balloon angioplasty. Eur Heart J., 2002; 23: 133-8.
9. Nishida T, Di Mario C, Kern MJ et al. Impact of final coronary flow velocity reserve on late outcome following stent implantation. Eur Heart J., 2002; 23: 331-40.
10. Kloner RA, Ganote CE, Jennings RB. The «no-reflow» phenomenon after temporary coronary occlusion in the dog. J Clin Invest.,1974; 54: 1496-1508.
11. Humphrey SM, Gavin JB, Herdson PB. Catecholamine-depletion and the no-reflow phenomenon in anoxic and ischaemic rat hearts. J Mol Cell Cardiol, 1982; 14: 151-161.
12. Humphrey SM, Seelye RN, Gavin JB. The influence of adenosine on the no-reflow phenomenon in anoxic and ischaemic hearts. Pathophysiology, 1982; 14: 129-133.
13. Westin M., Heden P. Calcitonin gene-related peptide delays the no-reflow enomenon in the rat island flap. Ann Plast Surg., 1988; 21: 329- 334.
14. Topol El, Mark DB; Lincoff AM et al. Outcomes at I year and economic implications of platelet glycoprotein lib/IlIa blockade in patients undergoing coronary stenting: results from a multicentre randornised trial. EPISTENT Investigators. Evaluation of Platelet lib/IlIa Inhibitor for Stenting. Lancet, 1999; 354: 2019-24.
15. Neumann FI, Zohlnhofer D, Fakhoury L, Ott I, Gawaz M, Schornig A. Effect of glycoprotein lIb/IlIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction. J. Am CoIl Cardiol., 1999; 34: 1420-6.
16. Komamura K, Kitakaze M, Nishida K, et al. Progressive decreases in coronary vein flow during reperfusion m acute myocardial infarction: clinical documentation of the no reflow phenomenon after successful thrombolysis. J Am Coll Cardiol, 1994; 24: 370-377.
17. Takahashi T, Anzai T, Yoshikawa T, et al. Absence of preinfarction angina ia associated with a risk of no-ieflow phenomenon after primary coronary angioplasty for a first anterior wall acute myocardial infarction. Int J Cordiol. 2000; 75: 253-260.
18. Kemp НК Jr. Syndrome-Х revisited. J Am Coll Cardiol, 1991; 17: 507- 508.
19. Rosenson R.S. Statin therapy: new therapy for cardiac microvascular dysfunction. Eur. Heart J., 2003; 24: 1993-1994.
20. Cannon R.O., Epstein S.E. “Microvascular angina” as a cause of chest pain with angiographically normal coronary arteries. Am. J. Cardiol, 1988; 61: 1338.
21. Meyer C, Schwaiger M. Myocardial blood flow and glucose metabolism in diabetes mellitus. Am J Cardiol., 1997;80(3A): 94A-101A.
22. Kollros PR, Konkle BA. Microvascular disease in diabetes mellitus. J. Cardiovasc Risk, 1997; 4: 70-5.
23. Ceriello A, Giacomello R, Stel G, et al. Hyperglicemia-induced thrombin formation in diabetes. Diabetes, 995; 44: 924-8.
24. Wiernsperger N.F., Bouskela E. Microcirculation in insulin resistance and diabetes: more than just a complication. Diabetes Metab., 2003; 23: 6S77-6S87.
25. Kayikcioglu М, Payzin S, Yavuzgil O. et al. Benefits of statin treatment in cardiac syndrome-Х. Еur Неагt J., 2003; 24: 1999-2005.
26. Fabian E, Varga А. Effect of simvastatin therapy on endothelial function of hypercholesteremic patients with syndrome-Х. Orv Hetil, 2002; 143: 2067-71.
27. Lee CH, de Feyter P, SerruysPW, Saia F, Lemos PA, Goedhart D, Soares PR, Umans V A W, Ciccone M, Cortellaro M. Beneficial effects of fluvastatin following percutaneous coronary intervention in patients with unstable and stable angina: results from the Lescol intervention prevention study (LIPS). Heart, 2004; 90: 1156-1161.
28. Walter DH, Fichtlscherer S, Britten MB et al. Initiation of tatin therapy immediately after stent implantation: profound benefit in patients with acute coronary syndromes (Abstr). Circulation, 2000; 244.
Review
For citations:
Alexandrov A.A., Tchukaeva I.I. MICROCIRCULATORY ISCHEMIA AND STATINS: LESSONS OF INTERVENTION CARDIOLOGY. Rational Pharmacotherapy in Cardiology. 2007;3(1):48-54. (In Russ.) https://doi.org/10.20996/1819-6446-2007-3-1-48-54
Views:
976
Email this article 