ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION
https://doi.org/10.20996/1819-6446-2013-9-1-35-39
Abstract
Aim. To access the role of endothelial adhesive dysfunction in the development of atrial fibrillation (AF) in patients with ischemic heart disease (IHD) complicated by chronic heart failure (CHF).
Material and methods. 111 patients with CHF class I–IV due to myocardial ischemia were included in the study. All participants were divided into four groups according to the presence of AF and CHF class. The control group consisted of 25 healthy individuals. Endothelial adhesive function was assessed by levels of soluble intercellular adhesive molecules sVCAM-1 and sE-selectin.
Results. The sVCAM-1 level in patients with CHF class III–IV with AF was significantly higher than this in control group and patients with CHF class I–II regardless of AF occurrence, as well as higher than this in patients with CHF class III–IV without AF (65%, 56.1%, 36.3% and 13.9%, respectively, p<0.05). Direct correlations between sVCAM-1 level and the left atrium volume index (LAVI) (r=0.52; p<0.05) and between sE-selectin level and LAVI (r=0.48; p<0.05) were revealed.
Conclusion. Endothelial adhesive dysfunction associates with AF existence and the severity of CHF.
About the Authors
A. N. Zakirova
Bashkir State Medical University, Ufa
Russian Federation
Russian Federation
E. R. Abdukova
Bashkir State Medical University, Ufa
Russian Federation
Russian Federation
N. E. Zakirova
Bashkir State Medical University, Ufa
Russian Federation
Russian Federation
References
1. Belenkov Yu.N., Mareev V.Yu. Treatment of heart failure in the 21st century: achievements, problems and lessons of medicine. Kardiologiia 2008; (2): 6–16. Russian (Беленков Ю.Н., Мареев В.Ю. Лечение сердечной недостаточности в 21 веке: достижения, вопросы и уроки доказательной медицины. Кардиология 2008; (2): 6–16).
2. Camm A.J. Atrial fibrillation and risk. Clin Cardiol 2012, 35 Suppl 1:1–2.
3. Guidelines for the management of atrial fibrillation. The Task Forse for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 2010; 31:2369–2429.
4. Zi D, Karen S, Leung T.K, Nattel S.Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 1999; 100:87–95.
5. Tarzimanova A.I., Fomina I.G.The role of inflammation in the pathogenesis of atrial fibrillation. Kardiovaskulyarnaya Terapiya i Profilaktika 2006; 5(7):91–93. Russian (Тарзиманова А.И., Фомина И.Г. Роль воспаления в патогенезе фибрилляции предсердий. Кардиоваскулярная Терапия и Профилактика 2006; 5(7):91–93).
6. Kumagai K, Nakashima H, Sakn K. The HMG-COA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in canine sterile pericarditis model. Cardiovasc Res 2004; 62:105– 11.
7. Engelmann MDM, Svedsen J.H. Inflammation in the genesis and perpetuation of atrial fibrillation. Eur Heart J 2005; 26:2083–92.
8. Price D.T., Loscalzo J. Cellular adhesion molecules and atherogenesis. Am J Med 1999; 107:85–97.
9. Oliveira G.H. Novel serologic markers of cardiovascular risk. Curr Atheroscler Rep 2005; 7;148–54.
10. Zakirova N.E., Oganov R.G., Zakirova A.N. Endothelial dysfunction in coronary artery disease. Rational Pharmacother Card 2008; 4:23–27. Russian (Закирова Н.Э., Оганов Р.Г., Закирова А.Н. Дисфункция эндотелия при ишемической болезни сердца. РФК 2008; 4:23–27).
11. Martynyuk T.V., Nakonechnikov S.N., Masenko V.P., Chazova I.E. Inhaled nitric oxide: clinical effects and influence on the profile of inflammatory markers in patients with idiopathic pulmonary hypertension. Rational Pharmacother Card 2012; 8(4):500–508. Russian (Мартынюк Т.В., Наконечников С.Н., Масенко В.П., Чазова И.Е. Ингаляционный оксид азота: клинические эффекты и влияние на профиль провоспалительных маркеров у пациентов с идиопатической легочной гипертензией. РФК 2012; 8(4):500–508.
12. Tzoulaki F. C-reactive protein, interleukin-6 and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population. Edinburgh artery study. Circulation 2005; 112:976– 983.
13. Zakirova A.N., Abdyukova E.R. Influence of β-blockers on cardiac remodeling and adhesive endothelial function in patients with coronary heart disease complicated with chronic heart failure and atrial fibrillation. Kardiologiia 2010; 3:11–15. Russian (Закирова А.Н., Абдюкова Э.Р. Влияние β-адреноблокаторов на ремоделирование миокарда и адгезивную функцию эндотелия у больных ишемической болезнью сердца, осложненной хронической сердечной недостаточностью и фибрилляцией предсердий. Кардиология 2010; 3:11–15).
14. ACC/AHA/ASE 2003 Guidelines Update to the Clinical Application of Echocardiography. Circulation 2003; 108(9):1146–62.
15. Gronefeld G.C., Hohnloser S.H. Heart failure complicated by atrial fibrillation: mechanistic, prognostic and therapeutic implications. J Cardiovasc Pharmacol Ther 2003; 8(2): 107–13.
16. Klein G, Szalay Z. Structural correlate of atrial fibrillation in human patients. Cardiovasc Rec 2002; 54(2): 361–79.
17. Hansson G.K. Inflammation, atherosclerosis and coronary artery disease. N Engl J Med 2005; 352(16): 1685–1695.
18. Lutay M.I., Golikova I.P., Deak S.I. Systemic inflammation in patients with coronary heart disease Ukrainskiy meditsinskiy zhurnal 2006; 2:80–83. Ukrainian (Лутай М.И., Голикова И.П., Деaк С.И. Системное воспаление у пациентов с ишемической болезнью сердца: Украинский медицинский журнал 2006; 2:80–83).
19. Marui N, Offermann M.K., Swerlick R. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression age regulated through an antioxidant – sensive mechanism in human valcular endothelial cells. J Clin Invest 1993; 92:1866–74.
20. Hwang S.J., Ballantyne C.B., Sharrett A.R. Circulating adhesion molecules VCAM-1, JCAM-1, and Eselectin in carotid atherosclerosis and incident coronary heart disease cases: the Aterosclerosis Risk In Communities (ARIC) Study. Circulation 1997; 96:4219–25.
21. Hasper D., Hummel M, Kleber E. Systemic inflammation in palients with heart failure. Eur Heart J 1998; 19:761–765.
22. Dernellis J., Panaretou M. Relationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillation. Eur Heart J 2004; 25:1100–107.
23. Nattel S. New ideas about atrial fibrillation 50 yearz on. Nature 2002; 415: 219–26.
Review
For citations:
Zakirova A.N., Abdukova E.R., Zakirova N.E. ENDOTHELIAL ADHESIVE FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE COMPLICATED BY CHRONIC HEART FAILURE AND ATRIAL FIBRILLATION. Rational Pharmacotherapy in Cardiology. 2013;9(1):35-39. (In Russ.) https://doi.org/10.20996/1819-6446-2013-9-1-35-39
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