EFFECTS OF ATORVASTATIN ON ENDOTHELIAL DYSFUNCTION IN TYPE 2 DIABETIC PATIENTS WITH DIFFERENT DURATION F THE DISEASE
https://doi.org/10.20996/1819-6446-2013-9-4-354-361
Abstract
Aim. To evaluate dynamics of endothelial vasoregulatory function in type 2 diabetic patients after 6 months of combined treatment with atorvastastin 20 mg/day depending on the disease duration and target lipid levels achievement.
Material and methods. The total of 161 type 2 diabetic patients with dyslipidemia were enrolled into non-randomized open-label study, of which 149 patients were assigned to a group of follow-up (group 1) and 12 to a group of comparison (group 2). All the patients received combined antihypertensive and glucose-lowering therapy. Patients of group 1 were additionally receiving atorvastatin 20 mg/day. Parameters of glucose and lipid metabolism and reactive hyperemia test were assessed in all patients initially and 6 months later.
Results. Patients with newly diagnosed diabetes were more likely to restore endothelial vasoregulatory function as compared to the patients with 1-5 and 6-10 years of diabetes duration (56% vs 42% and 35%, respectively). Patients who reached target lipid levels as compared with those who didn’t, more often revealed normalization of endothelial function (38% vs 33%, respectively). Atorvastatin benefited was more effective in newly diagnosed diabetic patients who had achieved target lipid levels.
Conclusion. Addition of atorvastatin to glucose-lowering and antihypertensive treatment can restore endothelial vasoregulatory function in 6 months in more than half of new-onset type 2 diabetic patients. Maximal effect of combined therapy with atorvastatin is obtained at early stages of diabetes mellitus and at target lipid levels achievement.
About the Authors
G. A. Batrak
Ivanovo State Medical Academy, Ivanovo
Russian Federation
MD, PhD, Assistant of Chair of Therapy and Endocrinology, Ivanovo SMA
Russian Federation
MD, PhD, Assistant of Chair of Therapy and Endocrinology, Ivanovo SMA
S. E. Miasoedova
Ivanovo State Medical Academy, Ivanovo
Russian Federation
MD, PhD, Prof., Head of the same Chair
Russian Federation
MD, PhD, Prof., Head of the same Chair
O. I. Kelesh
Municipal Clinical Hospital №4, Ivanovo
Russian Federation
MD, Department of Functional Diagnostics, MCH № 4
Russian Federation
MD, Department of Functional Diagnostics, MCH № 4
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For citations:
Batrak G.A., Miasoedova S.E., Kelesh O.I. EFFECTS OF ATORVASTATIN ON ENDOTHELIAL DYSFUNCTION IN TYPE 2 DIABETIC PATIENTS WITH DIFFERENT DURATION F THE DISEASE. Rational Pharmacotherapy in Cardiology. 2013;9(4):354-361. https://doi.org/10.20996/1819-6446-2013-9-4-354-361
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