ASSESSMENT OF CORONARY ATHEROSCLEROSIS PROGRESSION IN PATIENTS WITH FIVE YEAR HISTORY OF MYOCARDIAL INFARCTION DEPENDING ON THE STATIN THERAPY COMPLIANCE
https://doi.org/10.20996/1819-6446-2012-8-6-772-776
Abstract
Aim. To study the coronary atherosclerosis progression in patients with 5-year history of myocardial infarction (MI) depending on the statin therapy compliance. Material and methods. Patients (n=31) with a five year history of MI were involved into the study. Patients were divided into two groups depending on the statin therapy compliance during 5 years after MI: group 1 — patients with high compliance, group 2 — patients with low compliance. Assessment of the coronary angiography and lipid profile was performed first time in 2005–2006 during hospital treatment for MI and after 5 years again. Results. Increase in the proportion of patients with two and three coronary vessel disease was found after 5 years of observation, despite the high rate of percutaneous coronary intervention (77.4%) and hypolipidemic therapy. Hemodynamically significant restenosis was found in 11.8% (group 1) and 21.4% (group 2) of patients. Target total cholesterol level was reached only in 42.9% and 11.8% of patients in group 1 and 2, respectively. The target level of low density cholesterol was achieved in no one patient. Conclusion. The findings suggest that in patients with 5-year history of MI coronary atherosclerosis progresses regardless of the statin therapy compliance.
About the Authors
A. I. Chesnikova
Rostov State Medical University
Russian Federation
Russian Federation
V. A. Safronenko
Rostov State Medical University
Russian Federation
Russian Federation
A. V. Hripun
Rostov State Medical University
Russian Federation
Russian Federation
References
1. Gaining health. The European Strategy for the Prevention .and Control of Noncommunicable Diseases. Geneva: WHO; 2006. Available at: http://www.euro.who.int/__data/assets/pdf_file/0008/ 76526/E89306.pdf. Date of access: 18/10/12.
2. Arkhipovskiy V.L. Cardiovascular disease: prevalence, the main risk factors. Ekologiya Cheloveka 2007;(7):20–25. Russian (Архиповский В.Л. Сердечно-сосудистая патология: распространенность, основные факторы риска. Экология человека 2007;(7):20–25).
3. Arutyunov G.P. Coronary atherosclerosis. New data for a new look to the eternal problem. Serdtse 2007;4;(1):4–12. Russian (Арутюнов Г.П. Коронарный атеросклероз. Новые данные для нового взгляда на вечную проблему. Сердце 2007;4;(1):4–12).
4. Hockley T., Gemmill T. European Cholesterol Guidelines Report. 2007. Available at: http://www.policy-centre.com/downloads/European-Cholesterol-Guidelines07.pdf. London: London School of Economics, Policy Analysis Centre; 2007. Date of access: 18/10/12.
5. Boytsov S.A., Yakushin S.S., Nikulina N.N. et al. Age-dependent aspects of acute coronary heart disease incidence rate and mortality in men and women. Rational Pharmacother Card 2010;6(5):639– 644. Russian (Бойцов С.А., Якушин С.С., Никулина Н.Н., и др. Возрастные аспекты заболеваемости острыми формами ишемической болезни сердца и смертности от них у мужчин и женщин. .РФК 2010;6(5): 639–644).
6. National guidelines for cardiovascular prevention. Kardiovaskulyarnaya Terapiya i Profilaktika 2011; 10 (6) suppl 2: 1–30. Russian (Национальные рекомендации по кардиоваскулярной профилактике. Кардиоваскулярная терапия и профилактика 2011; 10 (6) Приложение 2: 1–30).
7. National guidelines for the diagnosis and correction of lipid disorders for prevention and treatment of atherosclerosis. Kardiovaskulyarnaya Terapiya i Profilaktika 2007;6 (6) suppl 3: 1–35. Russian (Национальные рекомендации по диагностике и коррекции нарушений липидного обмена с целью профилактики и лечения атеросклероза. Кардиоваскулярная Терапия и Профилактика 2007;6 (6) Приложение 3: 1–35).
8. Bokeriya L.A., Oganov R.G., eds. All about cholesterol: a national report. Moscow: NTsSSKh im. A.N. Bakuleva; 2010. Russian (Бокерия Л.А., Оганов Р.Г., редакторы. Все о холестерине: национальный доклад. М.: НЦССХ им. А.Н. Бакулева; 2010).
9. National guidelines for diagnosis and treatment of stable angina. Kardiovaskulyarnaya Terapiya i Pro-filaktika 2008; 7(6) suppl 4: 1–46. Russian (Национальные рекомендации по диагностике и лечению стабильной стенокардии. Кардиоваскулярная терапия и профилактика 2008; 7(6) Приложение 4: 1–46).
10. Karpov Yu.A., Samko A.N., Buza V.V. Coronary angioplasty and stenting. Moscow: Meditsinskoe In-formatsionnoe Agentstvo; 2010. Russian (Карпов Ю.А., Самко А.Н., Буза В.В. Коронарная ангиопластика и стентирование. М.: Медицинское Информационное Агентство; 2010).
11. Puchin'yan N.F., Dovgalevskiy Ya.P., Dolotovskaya P.V., Furman .N.F. The adherence to recommended therapy in patients after acute coronary syndrome, and risk of cardiovascular complications within a year after hospital admission. Rational Pharmacother Card 2011;7(5):567–573. Russian (Пучиньян Н.Ф., Довгалевский Я.П., Долотовская П.В., Фурман .Н.Ф. Приверженность рекомендованной терапии больных, перенесших острый коронарный синдром, и риск развития сердечно-сосудистых осложнений в течение года после госпитализации. РФК 2011;7;(5): 567– 573).
12. Ioseliani D.G., Gromov D.G., Sukhorukov O.E. et al. Surgical and endovascular revascularization in patients with multivessel coronary artery disease coronary bed: a comparative analysis of short-and longterm results. Mezhdunarodnyy Zhurnal Interventsionnoy Kardioangiologii 2008; 15: 22–31. Russian (Иоселиани Д.Г., Громов Д.Г., Сухоруков О.Е. и др. Хирургическая и эндоваскулярная реваскуляризация миокарда у больных ИБС с многососудистым поражением венечного русла: сравнительный анализ ближайших и отдаленных результатов. Международный журнал интервенционной кардиоангиологии 2008; 15: 22–31).
13. Skopets I.S., Vezikova N.N., Marusenko I.M. et al. Acute coronary syndrome: a comprehensive approach in tactics veedeniya patients, the role of primary and secondary prevention. Kardiosomatika 2011;2(1): 9–12. Russian (Скопец И.С., Везикова Н.Н., Марусенко И.М. и др. Острый коронарный синдром: комплексный подход в тактике веедения пациентов, роль первичной и вторичной профилактики. Кардиосоматика 2011;2(1): 9–12).
Review
For citations:
Chesnikova A.I., Safronenko V.A., Hripun A.V. ASSESSMENT OF CORONARY ATHEROSCLEROSIS PROGRESSION IN PATIENTS WITH FIVE YEAR HISTORY OF MYOCARDIAL INFARCTION DEPENDING ON THE STATIN THERAPY COMPLIANCE. Rational Pharmacotherapy in Cardiology. 2012;8(6):772-776. (In Russ.) https://doi.org/10.20996/1819-6446-2012-8-6-772-776
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