ARTERIAL STIFFNESS PARAMETERS IN PATIENTS WITH MODERATE/HIGH CARDIOVASCULAR RISK DURING LISINOPRIL AND SIMVASTATIN TREATMENT
https://doi.org/10.20996/1819-6446-2009-5-3-14-18
Abstract
Aim. To evaluate parameters of arterial stiffness by non-invasive arteriography in patients with moderate/high cardiovascular risk receiving lisinopril and simvastatin.
Material and methods. 20 patients (aged 50-55 y.o.) with arterial hypertension of the 1st degree and dislipidemia are included in the study. All patients had pulse wave velocity (PWV) ≥ 10 m/s and/or the corrected index of pulse wave augmentation (AI × 80) ≥ -10% according to non-invasive arteriography data; and moderate-high cardiovascular risk (≥ 3%). Patients received therapy with lisinopril and simvastatin. Blood pressure (BP) levels and lipid profiles were assessed before therapy and in 1, 2, 6 and 12 month of the observation. Non-invasive arteriography was performed before therapy and in 2, 6 and 12 months later.
Results. BP target levels were reached within 1 month of treatment as well as improvement of lipid profile was reached within 2 months in majority of the patients. Reference PWV and AI were reached in 85,7% of patients within one year of treatment.
Conclusion. Arterial stiffness parameters help to evaluate cardiovascular risk changes accurately as the results of treatment.About the Authors
V. N. Isakova
The Medical Centre “Prima Medica”,
The Far-Eastern State Medical University
Russian Federation
Russian Federation
Amursky bul. 57, Khabarovsk, 680021
ul. Muravyeva-Amurskogo 35, Khabarovsk, 680000
O. G. Garbuzova
The Medical Centre “Prima Medica”,
The Far-Eastern State Medical University
Russian Federation
Russian Federation
Amursky bul. 57, Khabarovsk, 680021
ul. Muravyeva-Amurskogo 35, Khabarovsk, 680000
E. V. Klinkova
The Medical Centre “Prima Medica”
Russian Federation
Amursky bul. 57, Khabarovsk, 680021
Russian Federation
Amursky bul. 57, Khabarovsk, 680021
E. V. Bandurko
The Medical Centre “Prima Medica”
Russian Federation
Amursky bul. 57, Khabarovsk, 680021
Russian Federation
Amursky bul. 57, Khabarovsk, 680021
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Review
For citations:
Isakova V.N., Garbuzova O.G., Klinkova E.V., Bandurko E.V. ARTERIAL STIFFNESS PARAMETERS IN PATIENTS WITH MODERATE/HIGH CARDIOVASCULAR RISK DURING LISINOPRIL AND SIMVASTATIN TREATMENT. Rational Pharmacotherapy in Cardiology. 2009;5(3):14-18. (In Russ.) https://doi.org/10.20996/1819-6446-2009-5-3-14-18
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