ПОДАВЛЕНИЕ АКТИВНОСТИ РЕНИН-АНГИОТЕНЗИНОВОЙ СИСТЕМЫ С ЦЕЛЬЮ ПРОФИЛАКТИКИ ОСЛОЖНЕНИЙ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ: СОВРЕМЕННОЕ РАСПРЕДЕЛЕНИЕ «РОЛЕЙ» С ТОЧКИ ЗРЕНИЯ КЛИНИЧЕСКОГО ФАРМАКОЛОГА

Обсуждают роль ингибиторов ангиотензин-превращающего фермента (АПФ) как средств лечения и профилактики сердечно-сосудистых заболеваний. Анализируют ряд крупных рандомизированных клинических исследований. Среди возможных факторов выбора ингибиторов АПФ рассматривают физико-химические свойства препарата и его доказательную базу. Также обсуждают проблему выбора ингибитора АПФ с целью вторичной профилактики осложнений сердечно-сосудистых заболеваний при артериальной гипертонии и после перенесенного инфаркта миокарда. Приходят к выводу, что выбор любого препарата для лечения сердечно-сосудистого заболевания определяется, прежде всего, его доказательной базой.

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