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The results of recent randomized controlled trials presented at the congress of the European Society of Cardiology: is everything so simple in evaluating their results?

https://doi.org/10.20996/1819-6446-2025-3243

EDN: MACRPX

Abstract

The results of RCTs presented at the recent Congress of the European Society of Cardiology are being analyzed. A number of RCTs with similar objectives have yielded formally opposite results. However, a thorough analysis of the methodological features of these RCTs reveals that the discrepancies between them are not significant. It is anticipated that the results of several RCTs may be challenging to integrate into the CR.

About the Author

S. Yu. Martsevich
National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia
Russian Federation


References

1. Bavendiek U, Großhennig A, Schwab J et al.; DIGIT-HF Study Group. Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2025 Aug 29. doi: 10.1056/NEJMoa2415471. Epub ahead of print.

2. van Veldhuisen DJ, Rienstra M, Mosterd A et al.; DECISION Investigators and Committees. Efficacy and safety of low-dose digoxin in patients with heart failure. Rationale and design of the DECISION trial. Eur J Heart Fail. 2024 Oct;26(10):2223-2230. doi: 10.1002/ejhf.3428. Epub 2024 Aug 30.

3. Cleland JGF, McMurray JJV, Freemantle N. Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction. N Engl J Med. 2024 Jul 4;391(1):94. doi: 10.1056/NEJMc2406095.

4. Watanabe H, Ozasa N, Morimoto T et al.; CAPITAL-RCT investigators. Long-term use of carvedilol in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. PLoS One. 2018 Aug 28;13(8):e0199347. doi: 10.1371/journal.pone.0199347.

5. Munkhaugen J, Kristensen AMD, Halvorsen S et al.; BETAMI–DANBLOCK Investigators. Beta-Blockers after Myocardial Infarction in Patients without Heart Failure. N Engl J Med. 2025 Aug 30. doi: 10.1056/NEJMoa2505985. Epub ahead of print.

6. Ibanez B, Latini R, Rossello X et al.; REBOOT-CNIC Investigators. Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction. N Engl J Med. 2025 Aug 30. doi: 10.1056/NEJMoa2504735. Epub ahead of print.

7. Lemesle G, Didier R, Steg PG et al.; AQUATIC Trial Investigators. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation. N Engl J Med. 2025 Aug 31. doi: 10.1056/NEJMoa2507532. Epub ahead of print.

8. Tarantini G, Honton B, Paradies V et al.; TARGET-FIRST Investigators. Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction. N Engl J Med. 2025 Aug 31. doi: 10.1056/NEJMoa2508808. Epub ahead of print.

9. Guimarães PO, Franken M, Tavares CAM et al.; NEO-MINDSET Trial Investigators. Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes. N Engl J Med. 2025 Aug 31. doi: 10.1056/NEJMoa2507980. Epub ahead of print.

10. Jøns C, Zheng C, Winsløw UCG et al.; POTCAST Study Group. Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias. N Engl J Med. 2025 Aug 29. doi: 10.1056/NEJMoa2509542. Epub ahead of print.

11. Flack JM, Azizi M, Brown JM et al.; BaxHTN Investigators. Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension. N Engl J Med. 2025 Aug 30:10.1056/NEJMoa2507109. doi: 10.1056/NEJMoa2507109. Epub ahead of print.

12. Garcia-Pavia P, Maron MS, Masri A et al.; MAPLE-HCM Investigators. Aficamten or Metoprolol Monotherapy for Obstructive Hypertrophic Cardiomyopathy. N Engl J Med. 2025 Aug 30. doi: 10.1056/NEJMoa2504654. Epub ahead of print.

13. Desai MY, Owens AT, Abraham T et al.; ODYSSEY-HCM Investigators. Mavacamten in Symptomatic Nonobstructive Hypertrophic Cardiomyopathy. N Engl J Med. 2025 Aug 30. doi: 10.1056/NEJMoa2505927. Epub ahead of print.

14. Bergmark BA, Marston NA, Prohaska TA et al.; Essence–TIMI 73b Investigators. Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia. N Engl J Med. 2025 Aug 30. doi: 10.1056/NEJMoa2507227. Epub ahead of print.

15. Johansen ND, Modin D, Loiacono MM et al. High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults. N Engl J Med. 2025 Aug 30. doi: 10.1056/NEJMoa2509907. Epub ahead of print.


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For citations:


Martsevich S.Yu. The results of recent randomized controlled trials presented at the congress of the European Society of Cardiology: is everything so simple in evaluating their results? Rational Pharmacotherapy in Cardiology. (In Russ.) https://doi.org/10.20996/1819-6446-2025-3243. EDN: MACRPX

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ISSN 1819-6446 (Print)
ISSN 2225-3653 (Online)