COMPLIANCE TO LONG-TERM TREATMENT OF CARDIOLOGIC PATIENTS WITH MILD TO MODERATE DEPRESSION: INEFFECTIVENESS OF ANTIDEPRESSIVE THERAPY WITH PIRLINDOL IN RANDOMIZED STUDY
https://doi.org/10.20996/1819-6446-2012-8-1-45-50
Abstract
Aim. To evaluate the influence of antidepressant therapy with pirlindol on compliance to the long-term treatment and quality of life in patients with cardiovascular diseases and mild to moderate depression. Material and methods. 61 patients with cardiovascular diseases and mild to moderate depression (according to Beck depression scale) were randomized into two groups. Patients of intervention group received pirlindol, while patients of control group did not receive this drug. Compliance to cardiovascular and antidepressant treatment were estimated in 3 and 6 months. Adverse reactions and patients self-assessment of their well-being and global satisfaction in treatmen were also registered. Results. 24 (75%), 2 (6%) and 0 patients of intervention group continue pirlindol treatment in 1, 3 and 6 months, respectively. In 3 months of observation patients of intervention group took drugs for cardiovascular diseases more often than these in control group (81% vs 72%, respectively , р<0.05), they also less frequently showed adverse reactions (56% vs 72%, respectively ,p=0.01) and more often — improvement of their well-being (65% vs 50%, respectively , р=0.03). Compliance to cardiovascular therapy did not differ significantly in patients of both groups by the end the study. Conclusion. Antidepressant therapy with pirlindol did not influence compliance to long-term cardiovascular treatment in patients with cardiovascular diseases and mild to moderate depression, apparently because of low compliance to pirlindol therapy.
About the Authors
E. V. Strokova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
E. A. Naumova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
J. G. Shvarts
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
References
1. Ushkalova E.A., Ushkalova A.V. Efficacy and safety of antidepressants in cardiac patients. Prakticheskaya Angiologiya 2006;3:28-32. Russian (Ушкалова Е.А., Ушкалова А.В. Эффективность и безопасность антидепрессантов у кардиологических больных. Практическая Ангиология 2006;3:28-32).
2. Mazza M., Lotrionte M., Biondi-Zoccai G. Selective serotonin reuptake inhibitors provide significant lower re-hospitalization rates in patients recovering from acute coronary syndromes: evidence from a metaanalysis. J Psychopharmacol 2010;24(12):85-92.
3. Zigmond A.S., Snaith R.P . The hospital anxiety and depression scale. ACTA Psychiatrica Scandinavica 1983;67:361-370
4. Beck A.T ., Ward C., Mendelson M. Beck Depression Inventory (BDI). Arch Gen Psychiatry 1961;4:561- 571.
5. Smulevich A.B., Syrkin A.L., Drobizhev M.Yu., Ivanov S.V. Psycho cardiology. M.: Meditsinskoe Informatsionnoe Agenstvo; 2005. Russian (Смулевич А.Б., Сыркин А.Л., Дробижев М.Ю., Иванов С.В. Психокардиология. М.: Медицинское информационное агентство; 2005).
6. Rayskiy V.A. Psychotropic drugs in the clinic of internal medicine. M.: Meditsina; 1988. Russian (Райский В.А. Психотропные средства в клинике внутренних болезней. М.: Медицина; 1988).
7. Nemeroff C.B. Evolutionary trends in the pharmacotherapeutic management of depression. J Clin Psychiatry 1994;55:3-15.
8. Naumova E.A., Shvarts Yu.G. Outpatient treatment of arterial hypertension. Physicians with a purpose and the real consumption of antihypertensive drugs. Klinicheskaya Farmakologiya i Terapiya 2000;4:19-
9. Russian (Наумова Е.А., Шварц Ю.Г . Амбулаторное лечение артериальной гипертонии. Мнения врачей, назначения и реальное потребление антигипертензивных препаратов. Клиническая Фармакология и Терапия 2000;4:19-21).
10. De Wilde J.E., Geerts S., Van Dorfe J. A double-blind randomized placebo-controlled study of the efficacy and safety of pirlindole, a reversible monoamine oxidase A inhibitor , in the treatment of depression. Acta Psychiatr Scand 1996;94:404-410
11. Pogosova G.V. Depression in patients with coronary artery disease and new possibilities of treatment. Psikhiatriya i Psikhofarmakoterapiya 2000;2:23-26. Russian (Погосова Г .В. Депрессия у больных ишемической болезнью сердца и новые возможности ее лечения. Психиатрия и Психофармакотерапия 2000;2:23-26).
12. Mikhaylova N.M., Siryachenko T.M. The practice of outpatient therapy with antidepressants. Russkiy Meditsinskiy Zhurnal 2005;13(10):693-699. Russian (Михайлова Н.М., Сиряченко Т .М. Практика амбулаторной терапии антидепрессантами. Русский Медицинский Журнал 2005;13(10):693- 699).
13. Adherence to long-term therapies. Evidence to action. Geneva: WHO; 2003. P .3-39, 65-71.
14. Aikens J.E., Nease D.E.Jr , Adherence to Maintenance-Phase Antidepressant Medication as a Function of Patient Beliefs About Medication. Annals of Family Medicine 2005;3:23-30.
15. Osterberg L., Blaschke T. Adherence to Medication. N Engl J Med 2005; 353(5): 487-497.
Review
For citations:
Strokova E.V., Naumova E.A., Shvarts J.G. COMPLIANCE TO LONG-TERM TREATMENT OF CARDIOLOGIC PATIENTS WITH MILD TO MODERATE DEPRESSION: INEFFECTIVENESS OF ANTIDEPRESSIVE THERAPY WITH PIRLINDOL IN RANDOMIZED STUDY. Rational Pharmacotherapy in Cardiology. 2012;8(1):45-50. (In Russ.) https://doi.org/10.20996/1819-6446-2012-8-1-45-50
Views:
739
Email this article 