THE EFFECT OF MAGNESIUM DRUGS ON THE PHYSICAL PERFORMANCE OF YOUNG PEOPLE WITH MITRAL VALVE PROLAPSE: RESULTS OF NONCOMPARATIVE STUDY
https://doi.org/10.20996/1819-6446-2012-8-6-752-755
Abstract
Aim. To study the dynamics of physical performance in young people with mitral valve prolapse (MVP) while taking magnesium orotate. Material and methods. Patients with MVP and phenotypic characteristics of undifferentiated connective tissue dysplasia (n=54, aged 19.2±0.3 years) were included into the study. Hemodynamic parameters of physical performance were evaluated before and after taking magnesium orotate for 8 weeks. Results. Improvement of physical performance was found after magnesium orotate taking: threshold double product elevated from 1.86±0.05 to 2.06±0.05 units (p<0.001); threshold power increased - relative physical performance raised from 1.35±0.04 W/kg to 1.44±0.04 W/kg (p<0.05) and specific work from 12.3±0.65 W/kg to 14.2±0.71 W/kg (p<0.001); recovery time decreased. Conclusion. Improvement of hemodynamic maintenance of exercise load was found in adolescents with MVP during magnesium orotate taking. It was accompanied with physical performance and threshold power elevation and recovery time reduction.
About the Authors
K. M. Dzeranova
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
A. G. Avtandilov
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
N. V. Vertkina
Municipal Clinical Hospital № 81
Russian Federation
Russian Federation
References
1. Veyn A. M., Solov'eva A. D., Nedostup A. V. et al. Autonomic disturbances in mitral valve prolapse. Kardiologiia 1995;35(2):55–58. Russian (Вейн А. М., Соловьева А. Д., Недоступ А. В. и др. Вегетативные нарушения при пролапсе митрального клапана. Кардиология 1995;35(2):55–58).
2. Zemtsovskiy E. V. Heart connective tissue dysplasia. SPb: TOO Politeks-Nord-Vest; 1998. Russian (Земцовский Э. В. Соединительнотканные дисплазии сердца. СПб: ТОО Политекс-Норд-Вест; 1998).
3. Martynov A. I., Stepura O. B., Ostroumova O.D. et al. Mitral valve prolapse. Part 1. Phenotypic characteristics and clinical presentation. Kardiologiia 1998; 38(1): 72–80. Russian (Мартынов А. И., Степура О. Б., Остроумова О.Д. и др. Пролапс митрального клапана. Часть 1. Фенотипические особенности и клинические проявления. Кардиология 1998; 38(1): 72–80).
4. Barlow J. B. Mitral valve billowing and prolapse — an overview. Aust NZJ Med 1992; 22 (Suppl 5): 541–549.
5. Kuznetsov G. P., Lebedev P. A.mitral valve prolapse. A manual for physicians and students. Samara: Sam GMU; 1997. Russian (Кузнецов Г. П., Лебедев П. А. Пролапс митрального клапана. Методическое пособие для врачей и студентов. Самара: Сам ГМУ; 1997).
6. Makolkin V. I. Can I use the term "functional heart disease." Ter arkhiv 1998; (8): 5–7. Russian (Маколкин В. И. Возможно ли использование термина «функциональные болезни сердца». Тер архив 1998; (8): 5–7).
7. Stepura O.B., Mel'nik O.O., Shekhter A.B. et al. The results of the magnesium salt of orotic acid "Magnerot" in the treatment of patients with idiopathic mitral valve prolapse. Rossiyskie Meditsinskie Vesti 1999; (2): 64–69. Russian (Степура О.Б., Мельник О.О., Шехтер А.Б. и др. Результаты применения магниевой соли оротовой кислоты «Магнерот» при лечении больных с идиопатическим пролапсом митрального клапана. Российские Медицинские Вести 1999; (2): 64–69).
8. Domnitskaya T.M., D"yachenko A.V., Kupriyanova O.O., Domnitskiy M.V. The clinical significance of magnesium orotate in adolescents with connective tissue dysplasia syndrome of heart. Kardiologiya 2005;45:76–81. Russian (Домницкая Т.М., Дъяченко А.В., Куприянова О.О., Домницкий М.В. Клиническое значение применения магния оротата у подростков с синдромом дисплазии соединительной ткани сердца. Кардиология 2005;45:76–81).
9. Alberts B., Johnson A., Lewis J., et al. Molecular Biology of the Cell. 4th ed. New York: Garland Science; 2002.
10. Yakupov I. F. Dynamics of cardiovascular teenage boys with mitral valve prolapse. Kazanskiy Meditsinskiy Zhurnal 2003; 84(5): 36–39. Russian (Якупов И. Ф. Динамика показателей сердечно-сосудистой системы юношей-подростков с пролапсом митрального клапана. Казанский Медицинский Журнал 2003; 84(5): 36–39).
Review
For citations:
Dzeranova K.M., Avtandilov A.G., Vertkina N.V. THE EFFECT OF MAGNESIUM DRUGS ON THE PHYSICAL PERFORMANCE OF YOUNG PEOPLE WITH MITRAL VALVE PROLAPSE: RESULTS OF NONCOMPARATIVE STUDY. Rational Pharmacotherapy in Cardiology. 2012;8(6):752-755. (In Russ.) https://doi.org/10.20996/1819-6446-2012-8-6-752-755
Views:
606
Email this article 