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Rational Pharmacotherapy in Cardiology

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Issue Title
 
Vol 15, No 3 (2019) Multi-Ethnic Analysis of Cardiac Pharmacogenetic Markers of Cytochrome P450 and Membrane Transporters Genes in the Russian Population Abstract  similar documents
K. B. Mirzaev, D. S. Fedorinov, D. V. Ivashchenko, D. A. Sychev
"... », «CYP4F2», «CYP4F1», «ABCB1», «SLCO1B1», «VKORC1», «GGCX», «SULT1A1», «CULT1», «CES1», «gene», «genes ..."
 
Vol 9, No 5 (2013) APPLICATIONS OF PHARMACOGENETIC TESTING FOR PERSONALIZATION OF THERAPY WITH ORAL ANTICOAGULANTS IN RUSSIA Abstract  similar documents
D. A. Sychev, R. E. Kazakov, V. A. Otdelenov, A. B. Prokofiev
"... anticoagulants choice on the basis of pharmacogenetic testing as well as indications for this approach ..."
 
Vol 3, No 2 (2007) VARFARIN DOSE REGIME APPROACHS BASED ON PHARMACOGENETICS TEST RESULTS: REAL POSSIBILITY TO OPTIMIZE THE PHARMACOTHERAPY Abstract  similar documents
D. A. Sychev, I. M. Antonov, S. V. Zagrebin, N. A. Gasanov, V. G. Kukes
"... of polymorphisms of genes of their biotransformation (CYP2C9) and molecule-targets (VKORC1). This created basis ..."
 
Vol 14, No 1 (2018) NEW APPROACHES TO INDIVIDUALIZED CHOICE OF ORAL ANTICOAGULANTS IN PATIENTS WITH ATRIAL FIBRILLATION Abstract  similar documents
Ju. P. Skirdenko, N. A. Nikolayev
"... , polymorphism of genes CYP2C9 and VKORC1 and the structure of food preferences. Results. Persons ..."
 
Vol 9, No 6 (2013) APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY Abstract  similar documents
D. A. Sychev, G. N. Shuev, A. B. Prokofiev
"... The clinical significance of the SLCO1B1 gene polymorphism (encoding an organic anion transport ..."
 
Vol 9, No 4 (2013) THE SIGNIFICANCE OF PHARMACOGENETIC CYP2C19 TESTING FOR PERSONALIZATION OF THE ANTIPLATELET THERAPY IN CARDIOLOGY PRACTICE Abstract  similar documents
K. B. Mirzaev, D. A. Sychev, D. A. Andreev, A. B. Prokofiev
"... is discussed. Approaches to antiplatelet agent choice according to pharmacogenetic CYP2C19 testing, as well ..."
 
Vol 4, No 2 (2008) EFFECT OF GENES SLCO1B1 AND MDR1 POLYMORPHISM ON ATORVASTATIN PHARMACOKINETICS AND PHARMACODYNAMICS IN PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA: RESULTS OF PILOT PHARMACOGENETICS STUDY Abstract  similar documents
A. V. Semenov, D. A. Sichev, V. G. Kukes
"... Aim. To study effects of genes SLCO1B1 and MDR1 polymorphism on atorvastatin pharmacokinetics ..."
 
Vol 13, No 3 (2017) PHARMACOGENETIC ASPECTS OF NEW ORAL ANTICOAGULANTS APPLICATION Abstract  similar documents
A. V. Kryukov, D. A. Sychev, O. V. Tereshchenko
"... rs1045642 and SLCO1B1 gene rs4149056 polymorphisms have no effect on edoxaban pharmacokinetics ..."
 
Vol 17, No 5 (2021) Pharmacogenetic Aspects of Postoperative Anesthesia with Ketoprofen in Cardiac Surgery Patients Abstract  similar documents
T. E. Morozova, D. A. Shatsky, N. V. Shikh, E. V. Shikh, T. B. Andrushchyshina, M. V. Lukina, A. A. Kachanova, Z. A. Sozaeva, G. N. Shuev, N. P. Denisenko, E. А. Grishina, D. A. Sychev
"... Aim. Evaluation of the effect of polymorphisms of the CYP2D6, CYP2C8 genes on the efficacy ..."
 
Vol 14, No 5 (2018) Pharmacogenetic and Clinical Predictors of Clopidogrel Insufficiency in a Patient with Atherosclerosis Obliterans of the Lower Extremities: Clinical Case Abstract  similar documents
M. A. Andreyanova, K. B. Mirzaev, D. A. Sychev, K. A. Ryzhikova, A. V. Pokrovsky, A. F. Kharazov
"... therapy in this patient, namely, the  carriage of polymorphic markers  of the  ABCB1 CT, CES1 CA and  CYP3 ..."
 
Vol 16, No 5 (2020) Pharmacokinetics and Pharmacogenetics of Apixaban Abstract  similar documents
A. V. Savinova, M. M. Petrova, N. A. Shnayder, E. N. Bochanova, R. F. Nasyrova
"... metabolized by CYP3A4 with minor contributions from CYP1A2, CYP2C8, CYP2C9, CYP2C19 and CYP2J2 isoenzymes ..."
 
Vol 13, No 6 (2017) CYP2C19 PHARMACOGENETIC TESTING FOR PERSONALIZATION OF ANTIPLATELET THERAPY IN PATIENTS WITH ACUTE CORONARY SYNDROME IN ROUTINE CLINICAL PRACTICE Abstract  similar documents
A. I. Akhmetova, E. B. Kleimenova, D. A. Sychev, O. V. Parshina, L. P. Yashina
"... Aim. To study the use of CYP2C19 pharmacogenetic testing (PhGT) for personalization ..."
 
Vol 6, No 4 (2010) CLOPIDOGREL PHARMACOGENETICS Abstract  similar documents
A. N. Meshkov
"... of clopidogrel play an important role in the resistance development. Allel variants of the gene cytochrome CYP2C ..."
 
Vol 16, No 5 (2020) New Pharmacogenetic Markers to Predict the Risk of Bleeding During Taking of Direct Oral Anticoagulants Abstract  PDF (Eng)  similar documents
K. B. Mirzaev, D. V. Ivashchenko, I. V. Volodin, E. A. Grishina, K. A. Akmalova, A. A. Kachanova, A. I. Skripka, R. M. Minnigulov, T. E. Morozova, O. A. Baturina, A. N. Levanov, T. V. Shelekhova, A. I. Kalinkin, D. A. Napalkov, A. A. Sokolova, D. A. Andreev, I. N. Sychev, P. O. Bochkov, D. A. Sychev
"... Aim. To search for new pharmacogenetic biomarkers of bleeding risk in patients taking rivaroxaban ..."
 
Vol 10, No 6 (2014) PHARMACOGENETIC TESTING OPPORTUNITIES IN CARDIOLOGY BASED ON EXOME SEQUENCING Abstract  similar documents
N. V. Shcherbakova, A. I. Ershova, A. A. Suvorova, E. Y. Hlebus, A. N. Meshkov, S. A. Boytsov
"... can be obtained by pharmacogenetic testing using data exome sequencing in patients with cardiac ..."
 
Vol 12, No 5 (2016) Treatment Adherence as a New Choice Factor for Optimization of Oral Anticoagulation Therapy in Patients with Atrial Fibrillation and Hemostatic Gene Polymorphisms Abstract  PDF (Eng)  similar documents
Yu. P. Skirdenko, A. V. Shustov, V. V. Zherebilov, N. A. Nikolayev
"... Aim. To evaluate treatment adherence and prevalence of CYP2C9 and VKORC1 gene mutations ..."
 
Vol 19, No 5 (2023) Pharmacogenetics and pharmacokinetics of rivaroxaban in patients with atrial fibrillation and chronic kidney disease Abstract  similar documents
N. A. Shatalova, D. A. Sychev, K. B. Mirzaev, A. I. Kochetkov, E. Yu. Ebzeeva, V. B. Dashabylova, P. O. Bochkov, S. N. Tuchkova, S. V. Glagolev
"... 1045642, rs1128503), CYP3A5 (rs776746), CYP3A4 (rs35599367) and CYP2J2 (rs890293) genes with residual ..."
 
Vol 18, No 6 (2022) Effect of ABCB1 Gene Carriage and Drug-Drug Interactions on Apixaban and Rivaroxaban Pharmacokinetics and Clinical Outcomes in Patients with Atrial Fibrillation and Deep Vein Thrombosis Abstract  similar documents
L. V. Fedina, I. N. Sychev, T. D. Rastvorova, E. V. Strigunkova, A. A. Kachanova, Z. A. Sozaeva, P. O. Bochkov, A. V. Vardanyan, K. B. Mirzayev, D. A. Sychev
"... apixaban together with a CYP3A4/P-gp inhibitor were 3.5 times more likely to have hemorrhagic complications ..."
 
Vol 17, No 1 (2021) Pharmacogenetics as a Way for Personalizing Diuretic Therapy: Focus on Torasemide Abstract  similar documents
N. M. Gafurova, E. V. Shikh, O. D. Ostroumova
"... of a patient. Pharmacogenetics of torasemide may be of significant importance for pharmacokinetics ..."
 
Vol 18, No 4 (2022) The effect of rs776746 polymorphism in the CYP3A5 gene on heart rate when using bisoprolol in patients with acute coronary syndrome Abstract  similar documents
V. A. Shumkov, K. A. Zagorodnikova, S. A. Boldueva, A. A. Murzina
"... Aim. The aim of this work was to study the occurrence of the rs776746 allelic variant of the CYP3A ..."
 
Vol 17, No 4 (2021) Evaluation of the Influence of CYP2C9* 2, CYP2C9*3 Gene Polymorphisms on the Efficacy and Safety of Postoperative Analgesia with Ketoprofen in Patients after Cardiac Surgery Abstract  similar documents
T. E. Morozova, D. A. Shatsky, N. V. Shikh, E. V. Shikh, T. B. Andrushchyshina, M. V. Lukina, A. A. Kachanova, Zh. A. Sozaeva, G. N. Shuev, N. P. Denisenko, E. A. Grishina, D. A. Sychev
"... therapy in patients with CYP2C9*2 (430C>T) rs179985 and CYP2C9*3 (1075A>C) rs1057910 gene polymorphisms ..."
 
Vol 17, No 1 (2021) Pharmacokinetics and Pharmacogenetics of Dabigatran Abstract  similar documents
A. V. Savinova, V. S. Dobrodeeva, M. M. Petrova, R. F. Nasyrova, N. A. Shnayder
"... , pharmacokinetics and pharmacogenetics of dabigatran are variable. This can affect both effectiveness and safety ..."
 
Vol 16, No 2 (2020) Algorithm for the Choice of Anticoagulant for Patients with Atrial Fibrillation Abstract  similar documents
Yu. P. Skirdenko, N. A. Nikolaev
"... of CYP2C9 and VKORC1 genes mutations were determined at the initial examination. These indicators were ..."
 
Vol 11, No 4 (2015) INFLUENCE OF THE CYP3A4 ISOENZYME METABOLIC ACTIVITY AND CYP2C19 GENE POLYMORPHISMS ON CLOPIDOGREL ANTIPLATELET EFFECT IN PATIENTS WITH ACUTE CORONARY SYNDROME UNDERGOING PERCUTANEOUS CORONARY INTERVENTION Abstract  PDF (Eng)  similar documents
K. B. Mirzaev, R. E. Kazakov, V. V. Smirnov, D. A. Andreev, D. A. Sychev
"... Aim. Carriership of CYP2C19*2 allelic variant and reduced CYP3A4 activity can affect the formation ..."
 
Vol 14, No 1 (2018) PHARMACOGENETIC STUDIES IN CARDIOLOGY: THE PROBLEM OF "DEPTH" OF THE ISSUE STUDY AND THE CORRECTNESS OF USING "GENETIC" TERMS Abstract  similar documents
D. A. Sychev, G. I. Lifshits
 
Vol 14, No 1 (2018) NFLUENCE OF CYP4F2*3 ON RESPONSE TO CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME Abstract  similar documents
K. B. Mirzaev, O. D. Konova, E. A. Grishina, K. A. Ryzhikova, Zh. A. Sozaeva, D. A. Andreev, M. Y. Gilyarov, D. A. Sychev
"... Background. Carriership of CYP4F2*3 (rs2108622, Val433Met) allelic variant can affect antiplatelet ..."
 
Vol 11, No 1 (2015) ASPECTS OF LIPID-LOWERING THERAPY WITH ATORVASTATIN IN PATIENTS WITH MYOCARDIAL INFARCTION FROM THE PERSPECTIVE OF PERSONALIZED MEDICINE Abstract  similar documents
M. V. Solodun, S. S. Yakushin
"... Aim. To analyze the impact of the SLCO1B1*5 (c.521T> C) and LIPC (C514T) genes polymorphisms ..."
 
Vol 20, No 1 (2024) Effect of CYP3A4/5, ABCB1 gene polymorphisms on the residual equilibrium concentration of apixaban and bleeding in patients with non-valvular atrial fibrillation and deep vein thrombosis Abstract  similar documents
l. V. Fedina, i. N. Sychev, K. V. Mirzaev, A. V. Vardanyan, S. V. Glagolev, A. A. Kachanova, P. O. Bochkov, R. V. Shevchenko, S. N. Tuchkova, I. V. Sychev, S. P. Abdullaev, D A. Sychev
"... Aim. The aim of our study was to investigate the influence of polymorphic markers of CYP3A4*22 CYP ..."
 
Vol 19, No 3 (2023) Recurrent bleeding during standard anticoagulant therapy in comorbid patients with atrial fibrillation: a clinical case report Abstract  similar documents
A. A. Kudriavtseva, E. V. Kolpachkova, Z. A. Gebekova, T. A. Sadulaeva, A. A. Sokolova, D. A. Napalkov
"... concentration of rivaroxaban, a pharmacogenetic study and the Thrombodynamics (TD) test were performed ..."
 
Vol 9, No 3 (2013) INTEGRATED ASSESSMENT OF STATIN-ASSOCIATED MUSCLE DAMAGE PREDICTORS IN PATIENTS WITH ISCHEMIC HEART DISEASE Abstract  similar documents
V. I. Petrov, O. N. Smuseva, Yu. V. Solovkina
"... into the study. Total plasma creatine kinase levels were measured and SLCO1B1*5 genotyping was performed ..."
 
Vol 6, No 4 (2010) ACC/AHA CLOPIDOGREL CLINICAL ALERT. WHAT MUST BE MODERN ANTIPLATELET THERAPY? Abstract  similar documents
S. J. Martsevich
 
Vol 14, No 4 (2018) Role of Single Nucleotide Polymorphism of СУР17А Gene in the Development of Stroke Abstract  similar documents
S. Yu. Nikulina, V. A. Shulman, A. A. Chernova, D. A. Nikulin, A. A. Semenchukov, O. V. Marilovceva, S. S. Tret'jakova, I. I. Lebedeva, V. N. Maksimov
"...  CYP17A1 is one of the many genes that can participate in the formation of predisposition ..."
 
Vol 17, No 5 (2021) Genetic Polymorphism of beta1-adrenergic Receptors and the Effect on the Clinical Efficacy of beta-adrenoblockers Abstract  similar documents
V. N. Larina, M. V. Leonova
"... was a systematic analysis of scientific data from pharmacogenetic studies on the role of beta1-adrenergic receptor ..."
 
Vol 13, No 4 (2017) GENETIC PREDICTORS OF INTENSIVE LIPID-LOWERING THERAPY EFFICACY AND ITS ANTI-INFLAMMATORY EFFECTS IN VERY HIGH CARDIOVASCULAR RISK PATIENTS Abstract  similar documents
M. A. Vorobyeva, M. M. Azova, O. O. Gigani, I. V. Garmash, S. V. Villevalde, Zh. D. Kobalava
"... , 62.1% of men) were included into the study. Polymorphism Phe189Ser of the CYP3A4 (gene encoding ..."
 
Vol 19, No 3 (2023) Association of polymorphic variants of CYP2C19, P2RY12, ITGB3, ITGA2 and eNOS3 genes with high residual platelet reactivity while taking clopidogrel and acetylsalicylic acid at different terms of myocardial infarction Abstract  similar documents
T. P. Pronko, V. A. Snezhitskiy, T. L. Stepuro, A. V. Kapytski
"... Aim. Study of the association of polymorphic variants of CYP2C19 (G681A), P2RY12 (H1/H2), ITGB3 (T ..."
 
Vol 11, No 5 (2015) Practical aspects of apixaban use in clinical practice: continuing the theme Abstract  similar documents
S. N. Bel'diev
"... Currently there are no generally accepted guidelines for the use of apixaban together with CYP3A4 ..."
 
Vol 11, No 2 (2015) PRACTICAL ASPECTS OF APIXABAN USE IN CLINICAL PRACTICE: VIEW POINT OF CLINICAL PHARMACOLOGIST Abstract  similar documents
D. A. Sychev, I. I. Sinitsina, G. Yu. Zakharova, M. I. Savel'eva, A. V. Ryabova, A. V. Kryukov, A. Yu. Yurovskii
"... laboratory control and monitoring are needed, drugs interactions (at the level of CYP3A4, P-gp), management ..."
 
Vol 18, No 3 (2022) Clinically Significant Drug Interactions for Direct Oral Anticoagulants: State of the Art Abstract  similar documents
S. R. Gilyarevsky
"... that are inhibitors or inducers of the CYP3A4 enzyme or P-glycoprotein enzymes, are determined by most of the drug ..."
 
Vol 12, No 5 (2016) Clinical and Laboratory Predictors of Major Adverse Cardiac Events in Patients with Ischemic Heart Disease Following Elective Percutaneous Coronary Intervention Abstract  similar documents
E. Z. Golukhova, M. V. Grigoryan, M. N. Ryabinina, N. I. Bulaeva
"... and laboratory biomarkers were assessed before stenting, as well as CYP2C19 genotyping after patient’s discharge ..."
 
Vol 18, No 3 (2022) Study the Association of Nucleotide Polymorphisms in Platelet Receptor and Cytochrome P450 Genes with the Development of Resistance to Antiplatelet Drugs in Patients with Coronary Artery Disease Abstract  similar documents
K. S. Semashchenko, T. S. Mongush, A. A. Kosinova, T. N. Subbotina, Y. I. Grinshtein
"... 2046934), ITGA2 (rs1126643), ITGB3 (rs5918), GP1BA (rs6065), CYP2C19*2 (rs4244285) genes ..."
 
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